Yes... but only if it's worth it.
If i truly believe in something i will stand for it, the majority does not make something true, though i'd be the minority at least i'd have my values and beliefs if you don't stand for something you will fall for anything that is not me.
Yes, I actually had to to this in a room full of people who disagreed with me on a pretty controversial topic. It is easy to stand up when everyone agrees with you, but if you can stand alone you will be well respected. After the debate on the topic a bunch of people came up to me and said what I did took alot of courage even though they disagree with me.
It's what I've been doing for nearly half a century now...