The relationship is over when one or both parties stop caring about the other. The signs are usually when the lines of communication break down, more fighting than times of peace. Usually at least one person is at fault although not always. Sometimes people just grow apart.
When he makes you pay rent and won't let you work, it's over.
Waking up alone is a good sign.
Is it always your fault? It takes two to have an argument.
So unless you are into drugs, alcohol, gambling, or crime, it is not all your fault.
When I say it is over
The relationship is over when one of two people give up.