depends on the cause...if you have a cold, with a runny nose at night, it is cause by postnasal drip, in which case lots of warm liquids, if it is a throat infection, or ear infection, then cold liquids and lozenges
Google ginger-lemon-honey remedy
Not a home remedy but just chug a bottle of Robitussin. You'll trip sack and forget all about your sore throat.
Hot whiskey with honey and lemon juice. It works nearly every time for me. Just slow sips, and let it go to work on the back of the throat.
Lemon and honey, ginger.