living in a pointless world
an unfulfilled life of sadness and misery
Losing someone precious to you.
Being a mother of physically handicapped children's who can't even move.
Complete financial destruction
Not living. By that, I mean being comatose or in a vegetative state.
Failure and embARASsment
Not being able to do what you want. Loss of freedom or independence
Being on the verge of death, suffering and in pain