Would you sedate a cat for traveling?

It depends on the cat, but yes I've sedated a cat for plane journeys before - it didn't seem to cause her any harm. Your vet should have a mild sedative that they can administer before the trip.

Cats can get car-sick, the same as humans, and so car trips can really stress them out. On the other hand, cats will generally associate car journeys with unpleasant experiences (like the vet), so that doesn't help either. If your cat is quiet enough to be held by a passenger, then you might want to try that in order to comfort him - but remember that (in some places) it's actually against the law to travel with an unrestrained cat in the car, due to the danger that he will freak out and distract you while you're driving.

Otherwise, you may want to try desensitizing him somewhat by putting him in his travel cage at home - even feeding him in there - and maybe taking him for a few short trips in the car (ones that don't end at the vet clinic!). I successfully trained a cat using this technique, and it got so that he was fine for really long trips in the car (like 8-10 hours at a time!). It definitely helped to take regular breaks while driving though, just to give him a chance to get some air and stretch his legs (on a lead - yes, I trained him for that too!).

Good luck. At least you'll only have to do it once! :)

Cats LOVE beer, get a 12 pack and a bucket of wings and your cat will be screaming "party!" the whole way there.

I used to enjoy having my cat perch on my shoulder on long trips. I brought a small litter box and some eats. If you want to sedate I recommend Valerian root - ask a vet how much. It's naturopathic, good 4U 2! Not while driving!!

Sure. I think cats would get sick on long car rides and she might end up throwing up and stuff. So I don't see why not, its only for a couple of hours and its to make her have a safe trip.