15 Year Zoloft User Starting On Bupropion (wellbutrin)

Feels good to write this down in words. Have been on Zoloft (Sertraline) 15 years. About 3 or 4 months ago I was in the worst depression I have ever experienced. Sure my business is slow and I have all the everyday stress that a family brings. This was different. Doing the most basic tasks were so exhausting. I feel like my brain has a foggy shield surrounding it. It's really starting to effect my family as well as myself. Like Lenny Kravitz' song I just want to get away I want to fly away. I use to be very social, fun, laughed a lot. Not anymore. Anyway I finally went to see the doc and she prescribed me 100mg Bupropion SR for one week and told me to up it to two doses after a week. She said to meet again in 6 weeks to see how it is going. If I feel better then she would ween off the (200mg) SertalineI. I am on day 4 with the 100mg Bupropion (Wellbutrin) and symptoms are worse if anything. I am willing to stick this out because i have heard it takes awhile. At this point most side affects would be fine with me if I can get out of this funk. BTW depression runs in the family. Anyway, I guess I was just curious if there is anyone else who was on zoloft (or any other med) for so long and it just stopped working and they tried Wellbutrin in conjuction with zoloft. Also is there any difference between the Bupropion and Wellbutrin? Thanks to all who posted on this site. Make you know you are not alone. I am a 44 year old male. 
An Ep User An EP User
5 Responses Jan 21, 2013

I have been on Zoloft for 26 yrs. Weaned twice over the years. I hate the weight gain and seems to not work anymore. Starting WB 150XL. Ill wait about a month to see how I feel. Unfortunately numb below the belt. No libeto....gained 20 pds. I think they all have these sort of side effects. They need to come up with something new and better for sure!

After a couple weeks on 100mg Bupropion SR I felt much better. I took one in the morning and one in the afternoon. This is in addition to 200 of zoloft. Had a buzzing feeling so after a few months I was switched to 150 once a day. Makes me super tired so may go back to the 2 100 or maybe even the 1 300 a day. I hate taking pills in both am and afternoon as I forget. In hind site buzzing is nothing compared to where I was before.

I wish I could tell you it gets better but because you switched to a completely different type of anti depressant I dont know how it will affect you. WB works on your dopamine while celexa works on your serotonin. I have issues with both which is why I take the wb and the zoloft. It could affect you positively or negatively. I hope negatively is not the case. If you were on celexa for so long why did you get off?

Thank you for your reply. I also hope it positively affects me. I am having weight and libido issues. I have always on celexa but want to see if wb works without them. My husband thinks I am crazy for switching. I am also hoping it will help with the irritability I have been feeling lately.

I hopw it works for you and you don't have to fo through the med changing process every month. When I initially got put on the wb it made me lose weight rather than gain ans I had more energy and was actually on celexa w it and unfortunately the wb increased my irritability and anxiety so my doc switched me from the celexa to the zoloft and I'm much more balanced now. It was such a process to get here and tried several diff meds but eventually I found what works best and am hoping this works for you

Thank you. I am going to try 3 weeks, urg! I have been getting terrible headaches too

Yes! The headaches...never had them until I went on wb they do get better though and if you ever get dizzy that'll slowly subside but they so both happen from time to time just not constant. Hang in there!

Headaches gone and dizziness is annoying. I feel much better, but I do not know if I can go more than 2 weeks with the dizziness. Thanks for your replies

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How are you doing now? I have been on celexa for longer than I can remember. I just switched to Wellbutrin 150 mg. it has been 4 days and I am sitting here crying. Depression also runs in my family. Please tell me this gets better and I am going to love wb

I have been taking zoloft for quite some time now and it works for my moods except I was lacking focus and motivation so my doc put me on the wellbutrin w the zoloft and it really has made a difference for me by simply balancing out the negative effects of the zoloft. There is a big difference between the two. Zoloft works on seratonin while wellbutrin works on dopamine. For me the wellbutrin gave me the focus and motivation I needed but the side effects aren't pleasing and I find they are more noticeable w the wellbutrin than the Zolof. I get dizzy constantly and get pounding headachea but in all honesty I feel much better than before w just one med. Everyone is different. Its been a few months hopefully everything worked out for the best.

Thank you, next week will be one month and I am feeling much better. Still have some crying bouts, but they are subsiding. The anger issues worried me, as I grabbed my sons color and pushed my daughter away. They are also subsiding. I am going to first therapy session today. Always hard for me in therapy when I am feeling better. I wish I could have gotten in when I was feeling low, easier for me to get the hurt out. Sometimes I feel like the meds just mask the hurt and depression. Is that a good thing? Shouldn't I be talking those out?

I think its very important to let out the masked things to your therapist because for one you will feel better getting them out even if they are buried and you feel better at the moment because they will just come up again at some point and two therapy will never help if the truth isn't coming out. I'm in school ro be an alcohol and drug counselor and I've learned in my schooling that being vulnerable can be a very important tool in releasing the negative and getting out the masked emotions in therapy. I know for me it can be so frustrating that I can't cry especially when I know I need it. Instead tears come out as frustration and anger so I think talking to your therapist about those bouts of anger is important as well. I hope this week brings positivity and love into your life and take care