Zoloft Great But Stopped Working After 10+ Years

About twelve years ago I was prescribed Zoloft for depression. It kicked in after a week or two and I was in heaven for months. The initial high subsided but my depression was gone. Zoloft was a great pill for me. About 3 or 4 months ago it seemed to just stop working. Huge fog, sleepiness, indecisiveness, and just wanting to fly away. Almost like i have been fighting this thing for so long my walls just finally caved in. Anyway I was curious if anyone else had been on zoloft (sertraline) for so long and then just stopped working. I am still on 200mg zoloft but started taking Wellbutrin in conjunction with it. On day 4 and not much change as of yet. The thought according to my doctor is that when or if Wellbutrin works we will start decreasing zoloft in 6 weeks. I hope it kicks in soon as I hate being a zombie. I consider myself lucky that zoloft worked for so long. It did make me less social then I use to be but for me it was worth it. From what I have heard Wellbutrin is like an upper and zoloft is like a downer and the two in many cases have canceled each other out. I am a 44 year old male with a family history of depression. Thanks for reading it just feels better to write this down in words.
An Ep User An EP User
3 Responses Jan 23, 2013

I have recently had the same experience. I was using Zoloft for 10 years straight and could handle almost anything. Lately I am having lots of trouble with depression and anxiety. It is not allowing me to live my life. I feel physically I'll.

I had a doctor suggest that going off it for a month and then going back on could increase it's effectiveness.
I didn't do it because I was afraid I'd start feeling bad. However, I'm getting back on it now and plan to make this a regular part of my routine on a yearly basis.

Hello =3!!

I had a friend who was on zoloft but she actually felt better when she was off of it. I hope you realize that these pills are just crap. They don't solve the root of the problem. Your environment has an effect on how you feel. These psychiatry industries are most of the time a joke because they just throw pills at people and don't reach them at the human level. They actually make up illnesses so that they can make a pill and put it out for the public. What I also hate about prescribing these pills, as that these people prescribing them act like there is something wrong with YOU, and not something offbeat with the way you just live your life.

I have found that finding a passion, something that inspires you to make a difference in this world can snap you right out of a depressive state. After all, people like to feel like their lives have meaning and that they are needed in this world :)

What gave me that sort of meaning was veganism and animal rights. It's like it woke me up and awakened my inner empathy. In a world that is becoming more and more apathetic, a resurgence of empathy, connection, and being aware of social issues (and then doing something about them!)would help create a world we'd all like to live in.

Anyway, this speech inspires a lot of people to make a difference in this world, I suggest you check it out.


you have no idea how someone else feel or whats in there mind, i have many passions that are considered my hobbies and i love them such as lifting weights, taking trips reading a book...etc i have been suffering for yrs and none of those gave me any kind of pleasure anymore, i need help like so many other people its not as easy as just finding something to inspire you out of depression.

I understand that your intentions are probably good, but one of the worst things you can say to someone with depression is that you can just snap out of it if you only do x or y. Depression is a real disease and most of us with it are suffering from a chemical imbalance for which medication is necessary.

I must disagree with you. If you knew that the pharmaceutical company was in so much cohoots with the psychiatric facilities, you'd realize how much of a scam most of it is.

A lot of depression is your "outlook" on life. Also, in psychology it explains that often depressive thoughts can lead to more depressive thoughts because you are kind of thinking about the same cues that make you remember other sad feelings. Yes, chemicals in your brain do make you feel bad or good, but there are cues that are pertinent to the individual that trigger such feelings. Depression is not a disease. It is not a "brain disorder." It is for the most part an outlook on life. I went through a mild case of what you may consider "depression" as a young kid when I was a loner, no one understood me, and I had gotten rejected, but when I healed and my outlook on life changed to one for the better, I began to feel a lot better, and I also learned what a lot of bull the psychiatry industry is.

Psychologists are cool and I'm studying psychology right now (there are many things don't forget that we are unsure of and don't know the answers to and can only make logical guesses. A lot of psychology is theories.) , but psychiatrists are leading you down a path where they make it seem like it that you are just a "messed up" individual and there is not something "bigger" in society going on. That's disgraceful to say to someone. Why so many cases of depression in the united states, hmmm? Are you meaning to tell me that so much of the population is NOT normal? You're not the problem. Society, and your outlook on life will determine your moods, and your feelings. Your brain understands what you consider to be of importance, and it understands your belief system of life that can be a factor in how you feel.

I'm not saying things happening to your brain can't be an affect, and there are some cases where actual trauma to the brain can jostle your thoughts, memories and feelings, but for the most part, if you are an otherwise normal individual, you are being fooled. Soon everyone will be on pills and people will think that's the norm because they won't know any other way. It's sad, and the pharmaceutical and psychiatric industries just laugh as they make heaps of money off people who want a "quick" fix to feel better instead of really working with the person to get them to a happier mentality and outlook on life. I had to develop this positive outlook on life , it didn't just come to me. It allows me to keep positive even through my dad's death while everyone else is grieving around me. Why aren't chemicals in my brain making me super sad and upset? Because I don't currently perceive death to be as emotionally draining and as of a loss as people make it out to be.

There is no miracle pill. People are stressed by the demands of society, wanting to fit in and be like everyone else, it's unsustainable and unhealthy and these companies advantage of that. Believe me or don't believe me, but I will be the one just shaking my head as most of the world throws their money at people looking for a way out of the feeling , when (for the most part) the only way out is to change it yourself. I can only tell you this. It's up to you to question the bigger picture of what is really going on here. Believe me or don't believe me, but I knew something had been up all along.

I understand where you're coming from and if it wasn't for an unfortunate event in my life I would most likely be agreeing with everything you said. The parts I do agree with is how the pharmaceutical industries have a huge control of the population and their perception of "normalcy". The so called developed societies of today are pretty much influenced (aka forced) to believe that they are only normal if they fit into x or y, and everybody else is an outcast, and let's face it, outcasts don't usually get far. That's what we're made to believe.

On the other hand, I still completely believe that depression does exist. I am sure that most people on anti-depressants today are not actually clinically depressed. I know the US has a bad habit of prescribing pills for everything, without really trying to dig deeper and spend the necessary time trying to treat people in different ways (cheaper ways), but I can assure you that a lot of people do suffer from a chemical imbalance which leads to depression. And for those people, these meds do a world of difference.

I do not live in the US. I live in Europe in a country where health care is free. In a country where doctors do not force pills down your throat. I also suffer from a very debilitating condition which will require me to receive a double lung transplant in the next few years (I'm a 29 year old). I have tried a lot of things that have worked, but I have reached a point where I could no longer have the motivation to live to see the transplant. Depressed people do not receive transplants because they feel the lungs would be wasted on someone who does not want to live (makes perfect sense), and that possibly would not comply to the treatments.
I decided myself to try Zoloft and it has changed my outlook on life. Once again, I have motivation to live.
Bear in mind that I also studied psychology and I am fully aware of the different ways in which we can get better and improve our outlook on life on our own. But a good psychologist is one that is also able to accept that the person in front of them might need more than therapy and a change in thought pattern.

Thanks for your mature response and sharing your outlook. It may have seen that way, but I would not have wanted to ban "all depression pills" because while I do still think depression is a made up illness, I know I can't speak for everyone since I'm not in their shoes and can't possibly understand exactly what they are going through, so I think if that's the road they want to take, they should have the option to take the pills I just don't think they should be so "available". I think I'd have less of a problem with these pills if they weren't so overprescribed, given to everyone and their neighbor, and even children. I feel like they should be a last resort and cognitive or behavioral thearpy, actually working with the person, should be used for the most part.

That's all really.

Take care.

1snowflake is an idiot...end of story. I have to take these meds becuae of an anxiety disorder brought about by withdrawal from one of them that should not have been prescribed. However, there is no way I could survive without them. I have been though cbt, and all sorts of other therapies. When my skin burns and my face burns and I feel electrical current tunning over my skin, ...well, trust me snowflake, you know not of what you speak. The brain is a huge ystery and I am appreciative that psychology and the science of exists. I used to be just like you...that was before the tables were turned. That's right I was prescribed cymbalta for hip pain and after 17 days of minimum dose I stopped taking it. I did not want to take it in the first place (have never been depressed or suffered from any kind of anxiety) but I gave in. Withdrawals lasted for months and I have never been through worse.....ever. Now I am stuck with anxiety disorder that only these meds can help with. YOu need to back off and understand that the brain is more complex than you think it is. Again, idiot.

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