I HATE EVERYTHING ABOUT POP-UPS.
Luckily, Safari (for Mac) does a pretty good job of keeping the pop-ups at bay. It's when I accidentally click on an ad (which I do quite a bit) that they seem to come out and play. (Ha! That so rhymes!)
I really hate the talking and flashing pop-ups. I also hate the ones that ask me to either pick yes or cancel and don't have any other way to close them. I'm always afraid to click cancel. But what am I supposed to do? They're evil and found a way to "get" me.
Damn them to hell.