For the past five years I have been on the Depot Shot and haven't experienced a period since that time, but I got off of it in January to assist with my weight lost. Since then my periods are awful. I have to take 800 mg pain killers like the kind you get after a surgery just to be able to deal with it all. The cramps, the sore back, the icky feeling, the butt cramps are all just too much for me to take right now. I'm making an appointment with the Health Dept. and getting back on my GD Depot!!!! I just can't do this anymore. It's just too uncomfortable for me right now.